Core Theme: Heart Failure
8.1 Diagnosis and Aetiology Assessment
The diagnosis of heart failure is a clinical puzzle. It relies on a triad: typical symptoms, specific signs, and objective evidence of structural or functional cardiac abnormality.
The Clinical Presentation: Symptoms and Signs
The classic presentation remains the breathless patient. However, the nuance lies in distinguishing cardiac breathlessness from respiratory causes.
Breathlessness (Dyspnoea): This is often exertional initially. As the ventricle stiffens or dilates, pressures rise in the left atrium, transmitting back to the pulmonary capillaries, causing interstitial oedema. This explains orthopnoea (breathlessness when lying flat) and Paroxysmal Nocturnal Dyspnoea (PND)—waking up gasping for air.
Fatigue: Often overlooked, this is a sign of"forward failure"—inadequate perfusion of skeletal muscles.
Oedema: Peripheral oedema is the hallmark of right-sided congestion. However, in 2026 practice, we recognize that visible oedema is a late sign. Trainees must look for"subclinical congestion" (elevated jugular venous pressure, hepatomegaly) before the ankles swell.
Clinical Pearl: In elderly patients,"confusion" or"reduced exercise tolerance" may be the only sign of heart failure, as they may not be active enough to experience classic exertional dyspnoea.
Investigating the Aetiology: The"Why"
Diagnosing"Heart Failure" is not a complete diagnosis; it is like diagnosing"fever." You must find the cause. The UK curriculum demands a rigorous hunt for the aetiology because it dictates the treatment.
Ischaemic Heart Disease (IHD): The most common cause. Previous myocardial infarctions scar the ventricle, leading to regional wall motion abnormalities (RWMA) and reduced contractility.
Valvular Heart Disease: Aortic stenosis (pressure overload) or mitral regurgitation (volume overload) can lead to ventricular remodeling.
Hypertension: Chronic high blood pressure forces the heart to pump against high resistance (afterload), causing Left Ventricular Hypertrophy (LVH). Eventually, the muscle stiffens (HFpEF) or burns out and dilates (HFrEF).
Dilated Cardiomyopathy (DCM): A diagnosis of exclusion, often familial or genetic.
Infiltrative Causes (The 2026 Focus): Amyloidosis (specifically ATTR-CM) is now diagnosed much more frequently thanks to better awareness. It presents with"red flags" like carpal tunnel syndrome, spinal stenosis, and a"sparkling" septum on echo.
Investigations: Characterizing the Myocardium
1. Natriuretic Peptides (NT-proBNP): This is the"rule-out" test. When the heart muscle stretches, it releases BNP. A normal level virtually excludes untreated heart failure. However, levels can be falsely low in obesity or falsely high in renal failure and atrial fibrillation.
2. Transthoracic Echocardiography (TTE): The workhorse of cardiology. It answers three key questions:
Structure: Are the valves working? Is the muscle thick (hypertrophy) or thin (dilation)?
Function: What is the Ejection Fraction (EF)? This classifies the patient into HFrEF (<40%), HFmrEF (41-49%), or HFpEF (≥50%).
Pressures: It estimates pulmonary artery pressures to screen for pulmonary hypertension.
3. Cardiac MRI (CMR): CMR is the gold standard for tissue characterization. While Echo sees the motion, MRI sees the tissue.
Scarring: Late Gadolinium Enhancement (LGE) can distinguish between ischaemic scarring (subendocardial) and non-ischaemic scarring (mid-wall or epicardial), which is crucial for determining aetiology in dilated cardiomyopathy.
Infiltration: It is definitive for diagnosing conditions like Sarcoidosis or Amyloidosis which may require specific enzyme replacement or immunosuppressive therapies.
Management of New-Onset Acute Heart Failure
When a patient presents acutely"wet" (congested), the immediate priority is decongestion.
Intravenous Diuretics: Furosemide is given intravenously to offload fluid. The 2026 standard involves early assessment of diuretic response (checking sodium in the urine) to escalate doses rapidly if the patient isn't responding ("diuretic resistance").
Vasodilators: Nitrates are used if the blood pressure is high to reduce the workload on the heart.
Oxygen/CPAP: Non-invasive ventilation is used if the patient is hypoxic and struggling to breathe, as it physically pushes fluid out of the alveoli.
8.2 Medical Optimization and Device Therapy
Once the patient is stable and"dry" (euvolemic), the focus shifts to prognostic medication. In 2026, the management of Heart Failure with Reduced Ejection Fraction (HFrEF) is one of the most evidence-based areas in all of medicine.
The Four Pillars of HFrEF Treatment
We no longer"step up" therapy slowly over months. The modern approach is the rapid sequencing or simultaneous initiation of the"Four Pillars." These drugs do not just treat symptoms; they fundamentally alter the biology of the failing heart and prolong life.
1. Beta-Blockers (Bisoprolol, Carvedilol, Nebivolol