: Felix Mueller
: Reversing Polycystic Kidney Disease The PKDproof program: A low-carb, high-nutrient approach to kidney health
: Hammersmith Health Books
: 9781781612460
: 1
: CHF 11.80
:
: Erkrankungen, Heilverfahren
: English
: 288
: Wasserzeichen
: PC/MAC/eReader/Tablet
: ePUB
A unique guide to the strategies developed by Felix Mueller, expert patient, influencer and author, over the past nine years to reverse his own polycystic kidney disease, as well as that of numerous clients and followers. The book shows the simple and easy diet and lifestyle changes that PKD patients - written off as 'incurable' - can make to radically prolong their time to, or even completely stave off, dialysis or transplant, and explains the scientific backgrounds of why this approach works according to emerging, as well as long-established, science. The book includes practical tips, daily routines, recipes, and a whole week meal plan as well as survival strategies for traveling and eating out without sacrificing kidney health in the process. Readers will learn that, contrary to popular belief, having PKD does not mean living in constant nutrient deficiency, but that food abundance can also lead to better health and even achieving the ultimate goal: drastically improving their kidney function and even size

Felix Mueller (Müller) describes himself as 'An unlicensed biohacker, a licensed filmmaker and a polycystic kidney disease (PKD) patient' who has immersed himself in finding ways to return his body to health since 2013. He has applied his knowledge to reducing his own kidney volume, as well as that of many others, and now 'at a bit over 30 years old my kidney function is the highest it has been in my life'. He specialises in helping people using a cyclical ketogenic diet, activating cell clean-up (autophagy) and adjusting their lifestyle to improve their outcomes with PKD. He has built a worldwide PKD community of PKD sufferers online that is growing all the time (see https://reversingpkd.com).

A mysterious substance in cyst fluid


So we have looked at injury of kidney cells earlier in this book (page5) and we have concluded that injuring a kidney cell in a PKD patient increases the chances of this cell becoming cystic as it switches to fermentation. The next question would be: is this always the case? Or is there an instance where injuring cells over and over does not lead to cyst growth and instead the cells retain the ability to heal and revert back to their healthy state? Yes, such cases have been described in several studies and they are highly intriguing. The question then becomes, what differentiates a cell that reacts to injury with uncontrolled growth from a cell that does not?

To elucidate this, I will take you down the path of some exciting research. As long ago as 1970, Darmady and colleagues had hypothesized that the expression of cysts in PKD might be connected to a specific toxin since the changes in renal structure were found at points where toxins were ‘maximally concentrated’.1 This was followed in 1995 by experiments using extracted cyst fluid from PKD patients, applied to healthy non-PKD tissue. The researchers found that this fluid stimulated ‘fluid secretion, cyclic adenosine monophosphate accumulation, and cell proliferation’, which are hallmarks of PKD, even though there was no mutation present. The toxins themselves were enough to exhibit the same effect.2

In the same year, a group of researchers led by JJ Grantham tried to dig deeper and used mass spectrometry to narrow the constituents of the cyst fluid down to a single substance that actually was responsible for triggering cyst growth. While they were able to concentrate the fluid to a point where its secretory activity was 48-fold above that of the original substance, meaning its ability to produce fluid that could fill a cyst was 48 times higher, they could not narrow it down to a single substance and described it as a fraction of lipids enriched in monoglycerides.3

Nine years before that, Avner had led a study in which he showed that complete regression of cystic changes was possible, after only 120 hours, when he removed the cell culture from its environment, thereby removing all of the present toxins as well.4

Endotoxin


Even though the mass spectrometry study didn’t yield conclusive results and bears repeating now that our technology has evolved further, we might still be able to look at other analyses of cyst fluid from PKD kidneys to shed more light on the issue.

Miller-Hjelle and colleagues in 1997 found the substance lipopolysaccharide (LPS), al