Twenty-five years after Bill Masen, the hero of the iconic 1951 cult novelDay of the Triffids,escapes with his family to a colony on the Isle of Wight, the human species is scattered all over the world as the deadly Triffid plants continue their devastating march.

One of the few human beings not blinded by the meteor shower of a quarter-century ago, David Masen, Bills son, has become a pilot, traveling in search of an effective weapon against the Triffids. In New York City, he discovers a group of people who appear to be immune to the Triffids deadly poison. But all is not as it seems in this colony, and soon David must face a dangerous adversary from his familys past.