Immune Biology of Brain Tumours
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Dimitrios K. Stavrou, Christian Hagel (Hrsg.)
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Immune Biology of Brain Tumours
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Dustri-Verlag
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9783871854606
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1
:
CHF 36.30
:
:
Klinische Fächer
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English
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246
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DRM
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PC/MAC/eReader/Tablet
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PDF
The excellent studies of numerous neuroscientists working in both basic and clinical research have yielded a significant number of highly interesting scientific insights in nervous system structure and function especially during the so-called “decade of the brain”. To review the wealth of new data is a difficult task even in the presence of electronic retrieval methods and modern means of communication. The decision to publish this book is based on the necessity to present relevant scientific discoveries in a defined area of the neurosciences in a compact and easy to read format. This is the more important as a review of the progress in different disciplines may stimulate collaboration between researchers in the field of neurooncology and thus facilitate the development of new techniques and strategies in the fight against malignant neurogenic tumours. Topics: Introduction – General considerations – Brain tumour immunology – Glioma associated antigens – Radioimmunoscintigraphy of gliomas – Applications of monoclonal antibodies in clinical neurooncology. 24 figures, 14 in colour, 11 tables.
Prologue
8
Acknowledgement
10
Contents
12
Contributors
14
1 Introduction
16
2.1 Tumour-specific and tumour-associated antigens
22
2.2 Immunological mechanisms of tumour cell destruction
38
2.3 Nonrandom immune escape of glioma cells by immune editing
48
3.1 CNS – immune system interplay under normal and pathological conditions
56
3.2 Expression of brain associated antigens in neuroepithelial cells
78
3.4 HLA class I antigen, antigen processing machinery component and NK cell ligand changes in astrocytic tumors: molecular mechanisms and clinical implications
96
3.5 Immune status of glioma patients
118
4.1 Glioma associated antigens in experimental rat brain tumours defined by monoclonal antibodies
126
4.2 Monoclonal antibody treatment of experimental Gliomas
138
4.3 Glioma cell lines established from human brain tumours
146
4.4 Generation of monoclonal antibodies against human glioma associated antigens and their clinical relevance
168
4.5 Expression of glioma associated antigens in human gliomas and glioma cell lines demonstrated by monoclonal antibodies
180
4.6 Optimizing monoclonal antibodies for application in patients
196
5.1 Radioimmunoimaging of human glioma xenografts in athymic mude mice
210
6.1 Inhibition of glioma angiogenesis by monoclonal antibodies
220
6.2 Radioimmunodetection and radioimmunotherapy of human gliomas
234
