| Contents | 11 |
---|
| Foreword I --- Larry Norton, MD | 6 |
---|
| Foreword II --- by Beryl McCormick, Clifford Hudis, and Patrick I. Borgen | 7 |
---|
| Preface | 9 |
---|
| Contributors | 14 |
---|
| I Principles and Practice | 16 |
---|
| 1 Breast Magnetic Resonance Imaging: Historical Overview --- Joo Young Melissa Lee and Elizabeth A. Morris | 17 |
| 1. Dynamic Approach | 17 |
| 2. Time Intensity Curves | 17 |
| 3. Morphologic Approach | 18 |
| 4. Combination of Dynamic and Morphologic Approaches | 19 |
| 5. Conclusion | 19 |
| References | 19 |
| 2 Breast Magnetic Resonance Imaging Techniques --- Nola M. Hylton | 21 |
| 1. MRI Versus Mammography | 21 |
| 2. Technical Requirements for Performing Breast MRI | 22 |
| 3. Imaging Coils | 23 |
| 4. Patient Preparation and positioning | 23 |
| 5. Image Acquisition Methods | 23 |
| 6. Fat Suppression | 26 |
| 7. Image Postprocessing | 26 |
| 3 Setting Up a Breast Magnetic Resonance Imaging Program --- Elizabeth A. Morris | 29 |
| 1. Patient Issues | 29 |
| 2. Personnel Issues | 30 |
| 3. Breast MRI Protocols | 30 |
| 4. Scheduling Considerations | 31 |
| 5. Patient Preparation | 31 |
| 6. Examination Interpretation | 33 |
| 7. Kinetic Analysis | 33 |
| 8. Communication of Results | 34 |
| 9. Interventional Issues | 34 |
| 10. Data Gathering | 34 |
| 11. Practice Growth Issues | 34 |
| 12. Coil Issues | 35 |
| 13. Selecting the Sequence | 35 |
| 14. Memorial Sloan-Kettering Cancer Center Sequence | 35 |
| 15. Conclusion | 36 |
| 4 The Normal Breast --- Elizabeth A. Morris | 37 |
| 1. Breast Anatomy | 37 |
| 2. Vessels | 43 |
| 3. Lymphatics and Lymph Nodes | 45 |
| 4. Pectoralis Major Muscle | 48 |
| 5. Breast Density | 49 |
| 6. Premenopausal Breast | 50 |
| 7. Postmenopausal Breast | 52 |
| 8. Chemopreventive Agents | 53 |
| 9. Pregnancy | 53 |
| 10. Skin and Nipple | 53 |
| 11. Fat | 57 |
| 12. Fibrous Tissue and Calcifications | 57 |
| 13. Conclusion | 57 |
| 5 The Axilla --- Joo Young Melissa Lee and D. David Dershaw | 59 |
| 1. Anatomy | 59 |
| 2. Pathophysiology of Metastatic Disease to Lymph Nodes | 59 |
| 3. Imaging Methods | 60 |
| 4. Magnetic Resonance Imaging of Lymph Nodes | 60 |
| 5. Identifying Metastatic Disease | 61 |
| 6. New Contrast Agents | 64 |
| 7. Conclusion | 64 |
| 6 Breast Magnetic Resonance Imaging Lexicon --- Elizabeth A. Morris | 65 |
| 1. Standardization of Terminology | 65 |
| 2. Technique | 66 |
| 3. Breast Histopathology and Magnetic Resonance Imaging | 67 |
| 4. Morphologic Features | 67 |
| 5. Description of Terms | 67 |
| 6. Value of T2 | 91 |
| 7. Kinetics | 91 |
| 8. Suggested Algorithm for Interpretation | 91 |
| 7 Dynamic Breast Magnetic Resonance Imaging --- Christiane K. Kuhl | 93 |
| 1. Pathophysiological Basis of Dynamic Contrast-Enhanced Breast Magnetic Resonance Imaging | 93 |
| 2. Technical Issues | 94 |
| 3. Choice of Pulse Sequences | 95 |
| 4. Generating the Source Data for Kinetic Analysis: Region of Interest Placement | 100 |
| 5. Analysis of Enhancement Kinetics | 102 |
| 6. Pharmakokinetic Modeling | 103 |
| 7. Understanding Published Literature:Survivors and One-Hit Wonders of Kinetic Approaches | 103 |
| 8. How To Use Information Obtainedfrom Dynamic Data | 105 |
| 9. Lesion Categorization: How We Integrate Morphologic and Kinetic Information | 113 |
| 10. Appearance of the Normal and the Diseased Breast in Dynamic Contrast-enhanced Breast Magnetic Resonance Imaging | 116 |
| 11. Current Applications of Dynamic Bilateral Breast Magnetic Resonance Imaging | 142 |
| 12. Future Directions | 149 |
| 8 Benign Lesions --- Andrea F. Abramson | 154 |
| 1. Mass Lesions | 154 |
| 2. Nonmass Lesions | 171 |
| 3. High-Risk Lesions | 176 |
| 9 Ductal Carcinoma In Situ --- Jennifer H. Menell | 178 |
| 1. Mammography and Ductal Carcinoma In Situ | 178 |
| 2. Magnetic Resonance Imaging and Ductal Carcinoma In Situ | 179 |
| 3. Magnetic Resonance Imaging of Mammographically Evident Calcifications | 179 |
| 4. False-Negative Results by Magnetic Resonance and Mammography | 180 |
| 5. Nuclear Grade | 180 |
| 6. Significant Ductal CarcinomaIn Situ Lesions on Magnetic Resonance Imaging | 180 |
| 7. Conclusion | 184 |
| 10 Magnetic Resonance Imaging of Invasive Breast Carcinoma --- Lia Bartella and D. David Dershaw | 187 |
| 1. Tumor Neovascularity and Angiogenesis | 187 |
| 2. Secondary Signs of Invasive Breast Cancer | 188 |
| 3. Types of Invasive Breast Cancer | 188 |
| 4. Invasive Ductal Carcinoma Not Otherwise Specified (NOS) | 188 |
| 5. Specialized Subtypes of Invasive Ductal Carcinoma | 189 |
| 6. Invasive Lobular Carcinoma | 191 |
| 7. Other Breast Malignancies | 192 |
| 8. Ductal Carcinoma In Situ Ve
|