Epidemiological and Molecular Aspects on Cholera Molecular and Epidemiological Aspects
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T. Ramamurthy, S.K. Bhattacharya
:
T. Ramamurthy, S.K. Bhattacharya
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Epidemiological and Molecular Aspects on Cholera Molecular and Epidemiological Aspects
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Springer-Verlag
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9781603272650
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1
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CHF 193.20
:
:
Klinische Fächer
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English
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372
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Wasserzeichen/DRM
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PC/MAC/eReader/Tablet
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PDF
Though cholera is an ancient disease, its perennial occurrence in several parts of the world has attracted many researches to find ways and means to combat the disease. The prevailing seventh pandemic cholera is dominating since 1961, but the dimension of the disease has taken several silhouettes, as the genetic structure and functions of the Vibrio cholerae has changed to a great extent. Several recent studies have shown that transformation of the pathogen at the molecular level has ameliorated several cholera outbreaks and epidemics of with successive new clones of V. cholerae. This comprehensive compilation, written by eminent international researchers reviews the epidemiology of cholera in Africa, Asia, Russia and Latin Americas. The other chapters contributed by acclaimed authors cover various aspects on evolution, polysaccaharide biosynthesis, SXT element, integrons, small molecule signalling systems, flagellar synthesis, filamentous phages, pathogenic role of proteases and hemolysin, and other putative virulence factors. In addition, ecology of V. cholerae and management of cholera were also discussed in detail. This book will be good source of information to all researchers with interests in infectious diseases, microbiology and molecular biology.
Preface
5
Contents
7
Contributors
9
1 General Introduction
12
2 Asiatic Cholera: Mole Hills and Mountains
16
2.1 Introduction
16
2.2 Cholera in the Indian Subcontinent
17
2.3 Other Asian Countries
19
2.4 Association Between V. cholerae and Parasites
20
2.5 The O139 Cholera
20
2.6 Antimicrobial Resistance
22
2.7 Phage Typing of V. cholerae O1 and O139
23
2.8 Molecular Epidemiology
24
2.9 Seroepidemiology
27
2.10 Prospects of Cholera Vaccines in Asia
28
2.11 Traditional Medicine and Food Habits for Prevention of Cholera
29
2.12 Control Measures and Health-Care Systems
29
2.13 Conclusion
31
References
31
3 Endemic and Epidemic Cholera in Africa
41
3.1 Introduction
41
3.2 Epidemics and Outbreaks
42
3.3 Risk Factors and Modes of Transmission of Cholera
44
3.4 The Organism
49
3.5 Seroepidemiology
50
3.6 Use of Antimicrobials
50
