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Oncothermia: Principles and Practices

:	Andras Szasz, Nora Szasz, Oliver Szasz
:	Oncothermia: Principles and Practices
:	Springer-Verlag
:	9789048194988
:	1
:	CHF 193.40
:

:	Nichtklinische Fächer
:	English

:	566
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option.

This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer.

Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe& Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey& Co.

	Contents	5
	Objective of the Book	10
	1 Oncology Treatments and Their Limits	13
	1.1 Cancer Short History and Efforts to Cure	13
	1.1.1 Historical Notes	13
	1.1.2 The ''War'' Against Cancer	14
	1.2 Paradigm and Challenges of Oncotherapies	19
	1.3 Limitations of Oncotherapies The Quest for a Step Forward	20
	1.3.1 Medical Challenge of Oncotherapies	22
	1.3.2 Ethical Challenge of Oncotherapies	23
	1.3.3 The Challenge of Evaluating the Results	23
	2 Hyperthermia Results and Challenges	28
	2.1 Hyperthermia Approach	28
	2.1.1 Definition of Hyperthermia in Oncology	28
	2.1.2 Basic Concepts of Oncological Hyperthermia	31
	2.1.3 Technical Variations of Hyperthermia in Oncology	34
	2.2 Effects of Hyperthermia	46
	2.2.1 Higher Baseline Temperature	46
	2.2.2 Vascular Changes	47
	2.2.3 Cellular Membrane Changes	49
	2.2.4 Lactic Acid Formation	50
	2.2.5 ATP Depletion	50
	2.2.6 Altered DNA Replication	52
	2.2.7 Enhanced Immune Reaction	52
	2.2.8 Pain Reduction	52
	2.2.9 Selective Gain of the Heat Resistance	52
	2.3 Clinical Oncological Hyperthermia	55
	2.3.1 Local and Whole-Body Heating	56
	2.3.2 Hyperthermia as a Complementary Method	59
	2.4 Hyperthermia Successes	63
	2.4.1 Brain Tumor Treatment by Hyperthermia	64
	2.4.2 Pancreas Tumor Treatment by Hyperthermia	68
	2.4.3 Lung and Bronchus	69
	2.4.4 Hepatocellular Carcinoma and Metastatic Tumors of the Liver	72
	2.4.5 Colo-Rectal Tumors	74
	2.4.6 Esophagus	75
	2.4.7 Head and Neck Localizations	75
	2.4.8 Gastric Tumors	76
	2.4.9 Breast Tumors	76
	2.4.10 Other Localizations Treated by Hyperthermia	78
	2.5 Hyperthermia Challenges in Oncology	83
	2.5.1 Challenge of Selection and Focus	87
	2.5.2 The Challenge of Temperature	88
	2.5.3 Medical Challenges of Hyperthermia in Oncology	94
	2.5.4 Challenge of Quality Control and Dosimetry of Hyperthermia	95
	2.5.5 What We Expect?	97
	2.5.6 Possible Solution: Oncothermia	98
	3 Thermo-Biophysics	100
	3.1 Factors of Physiology Heating	100
	3.2 Biothermodynamics	103
	3.2.1 Energy, Heat, and Temperature	104
	3.2.2 Energy of the Chemical Bonds and Reactions	108
	3.2.3 Energy Sources and Driving Forces	129
	3.2.4 Energy and Structure	132
	3.2.5 Energetics of Malignant Cells	133
	3.2.6 -	133
	3.2.6 -	133
	144	133
	3.3 Bioelectrodynamics	147
	3.3.1 Basic Interactions	149
	3.3.2 The Bioimpedance	150
	3.3.3	150
	3.3.3	150
	156	150
	3.3.4	150
	3.3.4	150
	160	150
	3.3.5 Membrane Effects	163
	3.3.6 Stochastic Processes	164
	3.3.7 Noises and Signals	167
	3.3.8 Resonances	173
	3.3.9 Modulation--Demodulation	177
	3.3.10 Special Field Effects of Biosystems	182
	4 Oncothermia - A New Kind of Oncologic Hyperthermia	184
	4.1 Oncothermia Characteristics	184
	4.1.1 Electrochemotherapy (ECT)	184
	4.1.2 Concept of Oncothermia	185
	4.1.3 Pennes Equation Revised	192
	4.1.4 Thermal Limit Problem	197
	4.1.5 Energy Transfer Through the Body Surface	198
	4.1.6 Penetration Depth	200
	4.1.7 Arrangement of Electrodes	201
	4.1.8 Far from Equilibrium	205
	4.1.9 Energy Intake and Temperature	208
	4.1.10 Macroscopic Focusing on the Tumor	212
	4.1.11 Heating the Extra-Cellular Electrolyte	216
	4.1.12 Temperature Gradient and Heat Flow on the Membrane	219
	4.1.13 Changes of the Membrane Potential	223
	4.1.14 Membrane Damage by Constrained Ion Currents	224
	4.1.15 Effect on Cell--Cell Connections	226
	4.1.16 Oncotherm Comparison	250
	4.2 Oncothermia Treatment Guidelines	251
	4.2.1 Treatment Planning	254
	4.2.2 Treatment Consensus	254
	4.3 Complementary Applications	258
	4.3.1 Complementary to Radiotherapy	258
	4.3.2 Complementary to Chemotherapy	259
	4.3.3 Clinical Toxicity, Safety	267
	4.4 Oncothermia Case Reports	268
	4.4.1 Near-Eye Treatments	268
	4.4.2 Brain Cases	270
	4.4.3 Gynecology Cases	276
	4.4.4 Gastrointestinal Cases	277
	4.4.5 Pulmonary Cases	290
	4.4.6 Other Cases	297
	4.5 Evaluation of Oncothermia Studies	297
	4.5.1 Evaluation Conditions	299
	4.5.2 Evaluation Methods	303
	4.6 General Overview on a Large Patients Pool	306
	4.7 Brain Studies	313
	4.7.1 Brain Safety Study (Phase I)	313
	4.7.2 Brain Efficacy Study (Phase II)	317
	4.7.3 Hungarian Brain Glioma Study	326
	4.7.4 Small Prospective, Double-Arm Brain Glioma Study	326
	4.7.5 Study of Brain Gliomas with Local Clinical Responses	328
	4.7.6 Brain Glioma Study with Relapses	328
	4.7.7 Bicentral Brain Glioma Study	329
	4.7.8 Oncothermia for Heavily Pretreated and Relapsed Brain Gliomas	333
	4.7.9 Study of Metastatic Brain Tumors	333
	4.7.10 Comparison of Oncothermia Brain Studies	334