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Vasculitis in Clinical Practice

:	Richard A. Watts, David G. I. Scott
:	Richard Watts, David G. I. Scott
:	Vasculitis in Clinical Practice
:	Springer-Verlag
:	9781849962476
:	1
:	CHF 44.60
:

:	Klinische Fächer
:	English

:	193
:	DRM
:	PC/MAC/eReader/Tablet
:	PDF

The systemic vasculitides are a group of disorders which are of increasing importance. Many of these conditions are only rarely encountered by general physicians and often present significant diagnostic challenges. Our goal in writing this short book was to provide easily accessible information in a pocket-sized format. We hope we have helped both the g- eral rheumatologist who only encounter these problems occasionally. We have focused on clinical presentation, di- nostic processes, and current management. We hope, the- fore, that we will help our patients with these potentially devastating conditions by improving diagnosis and therapy. Richard A. Watts Ipswich, UK David G. I. Scott Norwich, UK v Contents Part I Introduction 1 Defnitions 3 1 1 General Introduction 3 1 2 Defnitions 4 2 Classifcation and Epidemiology 7 2 1 Introduction 7 2 2 ACR (1990) Criteria 8 2 3 Chapel Hill Consensus Defnitions 9 2 4 Epidemiology 9 2 5 Etiological Factors 10 References 11 3 General Presentation of the Vasculitides 13 3 1 Introduction 13 3 2 Pattern Recognition 13 3 3 Laboratory Investigations 16 3 4 Differential Diagnosis 18 References 19 4 General Principles of Treatment 21 4 1 Treatment 21 4 2 Remission Induction 21 4. 2. 1 Large Vessel Disease . . . . . . . . . . . . . . 22 4. 2. 2 Medium Vessel Disease . . . . . . . . . . . . 22 4. 2. 3 Medium/Small Vessel Vasculitis . . . . . 22 4. 2. 4 Small Vessel Vasculitis . . . . . . . . . . . . .

Richard A. Watts, DM MA FRCP is a Senior Lecturer at the University of East Anglia School of Medicine, Health and Policy Practice and a Consultant Rheumatologist at Ipswich Hospital NHS Trust, in the UK.David G.I. Scott, MD FRCP is a Consultant Rheumatologist at Norfolk and Norwich University Hospital NHS Trust, and an Honorary Professor at the University of East Anglia, School of Medicine, Health Policy and Practice, in the UK.

	Vasculitis in Clinical Practice	2
	Preface	4
	Contents	5
	Contributors	16
	Abbreviations	17
	Part 1: Introduction	19
	Chapter 1: Definitions	20
	1.1 General Introduction	20
	1.2 Definitions	21
	Chapter 2: Classification and Epidemiology	24
	2.1 Introduction	24
	2.2 ACR (1990) Criteria	25
	2.3 Chapel Hill Consensus Definitions	26
	2.4 Epidemiology	26
	2.5 Etiological Factors	27
	Key Points	28
	References	28
	Chapter 3: General Presentation of the Vasculitides	29
	3.1 Introduction	29
	3.2 Pattern Recognition	29
	3.3 Laboratory Investigations	32
	3.4 Differential Diagnosis	34
	Key Points	34
	References	35
	Chapter 4: General Principles of Treatment	36
	4.1 Treatment	36
	4.2 Remission Induction	36
	4.2.1 Large Vessel Disease	37
	4.2.2 Medium Vessel Disease	37
	4.2.3 Medium/Small Vessel Vasculitis	37
	4.2.4 Small Vessel Vasculitis	39
	4.3 Maintenance Therapy	40
	4.4 Long-Term Follow-Up	40
	4.5 Relapsing Disease	40
	4.6 Refractory Disease	41
	4.7 Specific Drugs Used to Treat Vasculitis	42
	4.7.1 Cyclophosphamide	42
	4.7.2 Glucocorticoids	43
	4.7.3 Methotrexate	43
	4.7.4 Plasma Exchange	44
	4.8 Monitoring	44
	4.9 Patient Advice	45
	4.10 Detection and Prevention of the Adverse Effects of Therapy	45
	4.10.1 Osteoporosis	45
	4.10.2 Vaccinations	46
	4.10.3 Pneumocystis Jirovecii Infection	46
	4.10.4 Cyclophosphamide-Induced Bladder Toxicity	46
	Key Points	46
	References	47
	Part 2: Features of Individual Diseases	48
	Chapter 5: Giant Cell Arteritis	49
	5.1 Introduction	49
	5.2 Definition and Classification	49
	5.3 Epidemiology	50
	5.4 Etiology	50
	5.5 Clinical Features	51
	5.5.1 Systemic	51
	5.5.2 Craniofacial	51
	5.5.3 Ophthalmic	53
	5.5.4 Neurologic	53
	5.5.5 Extracranial Artery	53