| Contents | 6 |
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| Introduction to the Proceedings of the Fourth International Conference on Multi-Component Reactions and Related Chemistry | 8 |
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| Session 1: Catalysis and Multi-Component Reactions | 12 |
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| Recent Progress in Asymmetric Two-Center Catalysis | 13 |
| Efficiency in Chemistry: From Hydrogen Autotransfer to Multi-component Catalysts | 15 |
| Multi-component Reactions by Microwave-Assisted, Continuous Flow Organic Synthesis | 16 |
| A Potpourri of Recent Microwave-Assisted 2(1H)-Pyrazinone Chemistry | 18 |
| Efficient Construction of (Hetero)Aryl Substituted (Aza)Indoles by Pd-Catalyzed Multi-component Reactions | 20 |
| Chlorotrimethylsilane is an Efficient Promoter for the Biginelli Reaction | 22 |
| Three-Component Synthesis of Dihydropyrimidobenzimidazol Derivatives in the Presence of MgO as a Highly Effective Heterogeneous Base Catalyst | 22 |
| 24 | 22 |
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| [Hmim]TFA-Catalyzed Multi-component Reaction: Direct, Mild, and Efficient Procedure for the Synthesis of 1,2-Dihydroquinazolines | 22 |
| 26 | 22 |
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| Synthesis of Benzofurans Catalyzed by 1,4-Diazabicyclo[2,2,2]Octane in Solventless System | 28 |
| Silica Sulfuric Acid: Highly Efficient Catalyst for the Synthesis of Imidazo[1,2-a]pyridines Using Trimethylsilylcyanide or Cyanohydrins | 28 |
| 29 | 28 |
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| Efficient Construction of (Aza)Indolyl Ynones by Pd/Cu-Catalyzed Multi-component Reactions | 31 |
| Multi-component Synthesis of Pyridazine and Pyridazinoquinazoline Derivatives in the Presence of 12-Tungstophosphoric Acid | 33 |
| Research of Nanosized Metal Oxide Action on Regio- and Stereoselectivity of the Multi-component Hantzsch Reaction | 35 |
| Nanocrystalline Copper (II) Oxide-Catalyzed One-pot Synthesis of Polyfunctionalized Pyrans via a Three-Component Cyclocondensation | 35 |
| Nanocrystalline Copper (II) Oxide-Catalyzed One-pot Synthesis of Polyfunctionalized Pyrans via a Three-Component Cyclocondensation | 35 |
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| 38 | 35 |
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| Reference | 14 |
| Session 2: Multi-Component Reactions in Heterocyclic Chemistry | 39 |
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| Multi-component Synthesis of Heterocycles by Palladium-catalyzed Generation of Alkynones, Alkenones and Allenes | 40 |
| Multi-component Reactions as Useful Platforms to Explore the Chemical Space | 42 |
| Multi-component Heterocyclizations: Control of Chemo- and Regioselectivity | 44 |
| Multi-component Reactions of H2S with Aldehydes and Amines as an Efficient Route to Heterocycles and Thioaza-Crown Compounds | 46 |
| Cascade Recyclizations of 1H-Pyrrole-2, 3-diones: A Method of Unusual Heterocyclic Systems Construction | 49 |
| Alkyne-Induced Tandem Transformations of (Hetero)Annulated Five-, Six-, or Seven-Membered N-Heterocycles and a New MCR on This Motif | 49 |
| 51 | 49 |
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| N C and C C Recyclizations of Pyrimidinium Salts | 53 |
| Synthetic Approach to Highly Functionalized Mesocyclic Heterocycles by Coupling an Ugi or Passerini Reaction (PADAM Strategy) with a Pd-Mediated Cyclocarbonylation | 53 |
| 55 | 53 |
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| Solvent-Free Three-Component Condensation of Aldehydes and Malononitrile with Naphthols Affording 2-Amino-4H-chromenes | 57 |
| General Procedure for 2-Amino-4H-Chromenes | 57 |
| New Pyrido[3,2-c]pyridones and Pyrido[3,2-c]pyrazoles Accessible by a One-Step Multi-component Synthesis | 59 |
| Synthesis of 1-Hydroxyaryl-4-Acyl-5-Aryl-3-Hydroxy-3-Pyrrolin-2-Ones | 61 |
| Synthesis of Highly Stable, Unusual Charge-Separated Pyridinium-, Isoquinolinium-, Quinolinium-, and N-Methylimidazolium-Tetronic Acid Zwitterions | 61 |
| 63 | 61 |
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| Synthesis of 4(5)-Imidazolecarboxylic Acid Derivatives | 64 |
| Polyfunctional U-MCR Reagents: Convenient Pathway to Novel Heterocyclic Systems | 67 |
| One-Pot Synthesis of Pyridines by Cyclocondensation of Acetyl- and Benzoylpyruvates, Trimethyl Orthoformate, and Enamines | 69 |
| Unprecedented Multi-component Approach to 1,4-Diazepine- and 1,4-Benzodiazepine Ring Formation | 71 |
| Synthesis and Interaction with Butylamine of Methyl 6-Acyl-7-Phenyl-4,7-Dihydrotetrazolo[1,5-a]Pyrimidine-5-Carboxylates | 72 |
| One-Pot Synthesis of 5-Oxo-1,3,4,5-Tetrahydro-Pyrrolo[4,3,2-de]Isoquinoline-3-Carboxamides | 74 |
| Synthesis of 4-Acyl-5-Aryl-1-(2,2-dimethoxyethyl)-3-Hydroxy-3-Pyrrolin-2-Ones | 76 |
| Synthesis and Structure of Isopropyl 5-Methyl-7-aryl-4,7-Dihydrotetrazolo[1,5-a]Pyrymidine-6-Carboxylates | 78 |
| References | 41 |
| Session 3: Multi-Component Reactions in Drug Discovery | 80 |
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| Multi-component Reactions and Drug Discovery | 83 |
| Building Molecular Shape Diversity via Post-Ugi Annulations | 84 |
| A Fast and Efficient Approach to Small Molecular Weight Protein-Protein Interaction Antagonists Using MCR Chemistry | 86 |
| Molecular Diversification and Solid-Phase Synthesis of N-Acylpeptides for Antibiotic Screening | 88 |
| Convertible Products of Ugi Reaction Involving Azole Carboxylic Acids and tert-Butyl Isocyanide | 90 |
| Applications of Quinoxaline Synthesis via Isocyanide-Based MCR | 92 |
| Continued Evidence for the Utility of TMSCl as Promoter for Groebke-Blackburn Reactions: Synthesis of Imidazo[2,1-b][1,3]benzothiazoles | 92 |
| 94 | 92 |
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| Systematic Diversity-Oriented Synthesis Based on Ugi Reaction Products | 96 |
| Priaxon AG, a New Dimension in Drug Discovery | 99 |
| Isocyanide-Based Multi-component Reaction of Diamines: An Efficient Strategy for Assembling of Unique Heterocyclic Scaffolds | 100 |
| A Convenient Synthesis of Novel Heterocyclic Structures Containing 11-Oxo-6,11,12,13-tetrahydrodibenzo[b,g][1,5]oxazonine Fragment | 100 |
| 101 | 100 |
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| Synthesis of Substituted 3-Methyl-1-oxo-2,3,4,5-tetrahydro-1H-benzo[C]azepino-3-carboxamides | 103 |
| New Approach of Some Bifunctional Initials in U-4MCR | 105 |
| One-Step Assembly of Novel Carbamoyl-Substituted Heterocycle-Fused 1-Oxo-2,3-dihydro-1H-benzo[c]azepines | 106 |
| A Facile One-Pot Greener Synthesis and Antibacterial Activity of 2-Amino-4H-pyran Derivatives | 108 |
| Session 4: Novel Reagents for Multi-Component Reactions | 109 |
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| Pluripotent Substrates in Diversity-Oriented Synthesis | 112 |
| New Polyfunctional Reagents for Isocyanide-Based Multi-component Reactions | 114 |
| Products of Ugi Reaction Among Acid Hydrazides, Aldehydes, and Isocyanides with Added Diversity | 116 |
| Highly Functionalized Tricyclic N-Heterocycles by Coupling an Ugi MCR with a Tandem Pd(0)-Promoted SN2'-Heck Reaction | 116 |
| 118 | 116 |
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| Cascade Transformations of N-(1-Aryl-2-polychloroethyl)sulfonamides | 120 |
| New Strategy for the Synthesis of Fluorinated Compounds: Multi-component Reactions Including Fluoro-containing Building Blocks | 122 |
| A Multi-component Reaction Leading to a Phenalenone Derivative | 124 |
| Heteropoly Acids in One-Pot, Three-Component Synthesis of 4-Aminoquinazolines | 125 |
| Passerini Multi-component Reaction of Indane-1,2,3-trione, Isocyanides and 2-Furancarboxylic Acid | 127 |
| A Novel Route to the Synthesis of Fluoroalkylated Hexahydroimidazo[1,2-a]Pyridines | 128 |
| Exploiting the Secondary Amines and the Glycolaldehyde Dimer in the Ugi Reaction: Formation of a Novel Passerini Ugi Chimera Scaffold | 128 |
| 130 | 128 |
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| Three-Component Synthesis of 4´H-spiro [Adamantane-2,3´-isoqunolines] | 131 |
| Nonracemizable Isocyanoacetates for Multi-component Reactions | 133 |
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