| Preface | 5 |
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| Contents | 6 |
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| Contributors | 7 |
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| Chapter 1 | 8 |
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| Bone Structure, Development and Bone Biology | 8 |
| The Skeleton | 8 |
| Bone Formation and Degradation | 8 |
| Bone Architecture | 9 |
| Gross Morphology | 9 |
| Parts of a Long Bone | 9 |
| Microscopic Features of Bone | 11 |
| Blood Supply of Bone | 12 |
| Nerve Supply of Bones | 12 |
| Bone Cells | 13 |
| Osteoprogenitor Cells | 13 |
| Osteoblasts | 13 |
| Osteocytes | 13 |
| Osteoclasts | 14 |
| Bone Matrix | 15 |
| Collagen | 16 |
| Enzymes | 16 |
| Alkaline Phosphatase | 16 |
| The Hydrated (Muco)Polysaccharide Gels | 17 |
| Factors Important in Mineralization | 17 |
| The Regulation of Bone and Cartilage | 18 |
| Parathyroid Hormone | 18 |
| Calcitonin | 19 |
| Vitamin D | 19 |
| Vitamin A | 20 |
| Estrogens | 20 |
| Androgens | 20 |
| Growth Hormone | 20 |
| Proteolipids | 20 |
| Growth Factors | 21 |
| Transforming Growth Factor-Beta | 21 |
| Bone Morphogenetic Proteins | 21 |
| Other Growth Factors | 21 |
| Mechanosensory Systems and Stretch Studies (Wolff’s Law) | 22 |
| Suggested Readings | 22 |
| Chapter 2 | 23 |
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| Common Problems in Orthopedic Pathology Including Trauma, Reactive Conditions and Necrosis of Bone | 23 |
| Healing of Bone | 23 |
| Fracture Union | 24 |
| Complications | 25 |
| Distraction Osteogenesis (Callotasis/Ilizarov Lengthening) | 25 |
| Heterotopic Ossification | 26 |
| Myositis Ossificans | 26 |
| Reflex Sympathetic Dystrophy (Sudeck Dystrophy or Algodystrophy) | 27 |
| Bizzare Parosteal Osteochondromatous Proliferation (BPOP or Nora Lesion) | 28 |
| Osteonecrosis | 29 |
| Suggested Readings | 36 |
| Chapter 3 | 37 |
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| Arthropathies | 37 |
| Common Features of Arthropathies | 37 |
| Radiological Aspects of Arthropathies | 37 |
| Alignment | 38 |
| Bones | 38 |
| Cartilage | 38 |
| Distribution | 39 |
| Extraordinary Findings | 40 |
| Soft-Tissues | 40 |
| Specific Arthritidies | 40 |
| The Productive Arthritidies | 40 |
| Osteoarthritis | 40 |
| Neuropathic Arthropathy (Charcot’s Joints) | 42 |
| Calcium Pyrophosphate Dihydrate Crystal Deposition Disease (CPPD) | 44 |
| Hemophilia | 45 |
| The Destructive (Inflammatory) Arthritidies | 46 |
| Rheumatoid Arthritis | 46 |
| Juvenile Rheumatoid Arthritis (Juvenile Chronic Arthritis) | 49 |
| Septic Arthritis | 49 |
| Gout | 50 |
| Psoriatic Arthritis | 53 |
| Reactive Arthritis | 54 |
| Ankylosing Spondylitis | 54 |
| Pigmented Villonodular Synovitis | 55 |
| Productive and Destructive Arthropathies | 57 |
| Nondestructive and Nonproductive Arthropathies | 57 |
| Miscellaneous Joint-Related Conditions | 58 |
| Osteochondritis Dissecans | 58 |
| Synovial Chondromatosis (Synovial Chondrometaplasia) | 58 |
| Chondromalacia Patella | 58 |
| Suggested Readings | 60 |
| Chapter 4 | 61 |
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| Infections of Bones | 61 |
| Suggested Reading | 66 |
| Chapter 5 | 67 |
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| Metabolic Bone Disorders | 67 |
| Suggested Readings | 74 |
| Chapter 6 | 75 |
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| Bone Cysts | 75 |
| Unicameral Bone Cyst | 76 |
| Aneurysmal Bone Cyst | 78 |
| Subchondral Cysts | 81 |
| Osteoarthritic Cysts | 82 |
| Intraosseous Ganglion | 83 |
| Cartilage Forming Tumors | 84 |
| Chondroblastoma | 84 |
| Chondromyxoid Fibroma | 86 |
| Osteochondroma | 87 |
| Chondroma | 90 |
| Chondrosarcoma | 96 |
| Conventional Chondrosarcoma | 96 |
| Chondrosarcoma Variants | 98 |
| Mesenchymal Chondrosarcoma | 98 |
| Clear Cell Chondrosarcoma | 100 |
| Dedifferentiated Chondrosarcoma | 102 |
| Secondary Chondrosarcoma | 104 |
| Bone Forming Lesions | 105 |
| Bone Island | 105 |
| Osteoma | 107 |
| Osteoid Osteoma | 107 |
| Osteoblastoma | 110 |
| Osteosarcoma | 112 |
| Conventional Osteosarcoma | 112 |
| Parosteal Osteosarcoma | 114 |
| Periosteal Osteosarcoma | 116 |
| Telangiectatic Osteosarcoma | 118 |
| Other Variants of Osteosarcoma | 122 |
| Fibrous and Fibrohistiocytic Tumors | 124 |
| Nonossifying Fibroma | 124 |
| Fibrous Dysplasia | 126 |
| Osteofibrous Dysplasia | 130 |
| Desmoplastic Fibroma | 132 |
| Fibrosarcoma of Bone | 133 |
| Malignant Fibrous Histiocytoma | 135 |
| Ewing Sarcoma | 136 |
| Giant Cell Lesions | 140 |
| Giant Cell Tumor | 140 |
| Giant Cell Reparative Granuloma | 143 |
| Adamantinoma | 147 |
| Notochordal Tumors | 149 |
| Chordoma | 149 |
| Benign Notochordal Cell Rest | 152 |
| Vascular Neoplasms | 152 |
| Hemangioma | 153 |
| Epithelioid Hemangioma | 154 |
| Angiomatosis | 155 |
| Massive Osteolysis | 155 |
| Hemophilic Pseudotumor | 156 |
| Epithelioid Hemangioendothelioma | 156 |
| Angiosarcoma of Bone | 158 |
| Hematopoietic Tumors | 158 |
| Plasma Cell Neoplasms (Plasma Cell Myeloma and Plasmacytoma) | 160 |
| Granulocytic Sarcoma | 160 |
| Non Hodgkin Lymphoma | 161 |
| Hodgkin Lymphoma | 161 |
| Langerhans Cell Histiocytosis | 161 |
| Erdheim Chester Disease | 162 |
| Other Hematopoietic Disorders | 162 |
| Suggested Readings | 163 |
| Chapter 7 | 164 |
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| Tumors and Tumor-Like Lesions of the Soft-Tissues | 164 |
| Soft-Tissue Tumors | 164 |
| Vascular Tumors | 164 |
| Capillary Hemangioma (Pyogenic Granuloma) | 164 |
| Cavernous Hemangioma | 165 |
| Histocytic (Epithelioid) Hemangioma (Angiolymphoid Hyperplasia with Eosinophilia) | 166 |
| Intramuscular Hemangioma (Intramuscular Angiolip
|