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Transporters as Targets for Drugs

:	Susan Napier, Matilda Bingham
:	Susan Napier, Matilda Bingham
:	Transporters as Targets for Drugs
:	Springer-Verlag
:	9783540879121
:	1
:	CHF 189.50
:

:	Nichtklinische Fächer
:	English

:	254
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

In each volume of Transporters as Targets for Drugs an overview chapter introduces the newcomer to the topic covered. The series covers hot topics of frontier research summarized by reputed scientists in the field.

	Volume Editors	5
	Editorial Board	5
	Topics in Medicinal Chemistry Also Available Electronically	6
	Preface to the Series	7
	Preface to Volume 4	8
	Contents	9
	Overview: Transporters as Targets for Drug Discovery	10
	1 Introduction	11
	2 Transporter Classification	11
	3 NSS Transporter Assays	14
	4 Transporters and Structure-Based Drug Design (SBDD)	15
	5 Transporters as Targets for Drug Discovery	17
	6 Summary	20
	References	20
	Membrane Transporters: Structure, Function and Targets for Drug Design	23
	1 Introduction	25
	2 Membrane Protein Structures	27
	3 Membrane Transporter Proteins	28
	4 Structure Determination of Membrane Proteins	32
	5 Transporters of Known 3D Structure	37
	6 Potential for New Drug Development	44
	7 Conclusions	54
	References	55
	Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs	60
	1 Introduction	61
	2 Selective Serotonin Reuptake Inhibitors	64
	3 Dual Serotonin and Noradrenaline Reuptake Inhibitors	72
	4 Noradrenaline Reuptake Inhibitors	87
	5 Conclusions	98
	References	98
	Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine s Mechanism at the Dopamine Transporter	102
	1 Introduction Chemical and Pharmacological Diversity of Dopamine Uptake Inhibitors	103
	2 Case Study: Benztropine Analogues	104
	3 Design, Synthesis and SAR of the Benztropine Analogues	106
	4 In Vivo Findings	116
	5 Mechanisms for Differences with Cocaine	121
	6 Preclinical Assessment of Cocaine-Abuse Therapy	130
	7 Summary and Conclusions	133
	References	134
	The Design, Synthesis and Structure Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors	137
	1 Introduction	138
	2 Overview of Dual-Uptake Inhibitors	140
	3 Design, Synthesis and Structure Activity Relationship of Triple- Uptake Inhibitors	143
	4 Conclusions	157
	References	158
	Molecular Imaging of Transporters with Positron Emission Tomography	161
	1 Introduction	163
	2 PET Principles	164
	3 PET Studies of Transporters	170
	4 Conclusions	186
	References	187
	Pharmacology of Glutamate Transport in the CNS:Substrates and Inhibitorsof Excitatory Amino Acid Transporters (EAATs)and the Glutamate/Cystine Exchanger System x c	193
	1 Introduction	195
	2 Excitatory Amino Acid Transporters (EAATs)	196
	3 System x c : Cystine/Glutamate Exchanger	214
	References	223
	Glycine Transporters and Their Inhibitors	229
	1 Introduction	230
	2 Glycine Transporter Isoforms	230
	3 Distribution	231
	4 Function	232
	5 Therapeutic Potential	233
	6 Medicinal Chemistry of Glycine Transporter Inhibitors	235
	7 Conclusion	247
	References	247
	Subject Index	254