Left-Right Asymmetry in Vertebrate Development
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M.L. López-Gracia, M.A. Ros
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Left-Right Asymmetry in Vertebrate Development
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Springer-Verlag
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9783540363484
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Advances in Anatomy, Embryology and Cell Biology
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1
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CHF 135.30
:
:
Nichtklinische Fächer
:
English
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126
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Wasserzeichen/DRM
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PC/MAC/eReader/Tablet
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PDF
Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.
List of Contents
6
Acknowledgements
7
Abbreviations
8
1 Introduction
11
2 Establishment of Left Right Asymmetry
23
3 Signaling Pathways with a Predominant Role in Left Right Patterning
45
4 Mouse Models of Laterality
54
5 Genetics of Human Alterations of Organ Situs
80
6 Concluding Remarks
90
References
106
1 Appendix
125
2 Glossary
129
Subject Index
133
