: David Cooper
: The Molecular Genetics of Lung Cancer
: Springer-Verlag
: 9783540269540
: 1
: CHF 96.60
:
: Nichtklinische Fächer
: English
: 392
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk.

The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.

Preface6
Acknowledgements9
Table of Contents10
An Introduction to the Molecular Basis of Cancer14
Lung Cancer: Setting the Scene31
Genes Involved in Sporadic Forms of Lung Cancer56
Somatic Mutation in Lung Cancer96
Genetic Approaches to Studying the Association Between Smoking and Lung Cancer130
Evidence for Genetic Susceptibility to Lung Cancer Derived from Polymorphism- disease Association Studies153
Gene Expression Studies in Lung Cancer177
Lung Cancer Pathogenesis and Future Prospects for Treatment and Prevention197
Relevant Websites207
Glossary212
Tables221
References287
Subject Index374