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Anxiety and Anxiolytic Drugs

:	Florian Holsboer, Andreas Ströhle
:	Florian Holsboer, Andreas Ströhle
:	Anxiety and Anxiolytic Drugs
:	Springer-Verlag
:	9783540280828
:	1
:	CHF 273.70
:

:	Pharmazie
:	English

:	566
:	Wasserzeichen/DRM
:	PC/MAC/eReader/Tablet
:	PDF

The present volume gives a comprehensive overview on the current state of basic and clinical research onAnxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment. In parallel, new drug targets have been generated and the first clinical studies with new compounds have been started. In 20 chapters written by numerous experts in the field comprehensive information on all relevant topics is provided.

	Preface	6
	List of Contents	11
	List of Contributors	13
	Learning and Memory	14
	1 Introduction	15
	2 Behavioural Paradigms for Studying Aversive Memories	16
	3 Animal Models	20
	4 Neurological Substrates of Aversive Memories	22
	5 Cellular Mechanisms Underlying Aversive Learning and Memory	26
	6 Clinical Implications	36
	References	38
	Animal Models of Anxiety	48
	1 Introduction	49
	2 Tests for Anxiety	51
	3 Animal Models	62
	4 General Conclusions	72
	References	73
	Genetic Alterations of the Murine Serotonergic Gene Pathway: The Neurodevelopmental Basis of Anxiety	83
	1 Introduction	84
	2 Anxiety-Like Behavior in Knockout Mice	85
	3 Functional Neuroanatomy of Emotionality: Focus on the Serotonin System	86
	4 Clinical Implications and Outlook	113
	References	114
	Mutagenesis and Knockout Models: Hypothalamic Pituitary Adrenocortical System	125
	1 Introduction Understanding Endocrine-Behavior Interactions: Lessons from Mutant Mice	126
	2 The Stress Hormone (Hypothalamic Pituitary Adrenocortical) System	127
	3 Gene Targeting: Promises and Caveats	134
	4 Summary	144
	References	145
	Mutagenesis and Knockout Models: NK1 and Substance P	154
	1 Introduction	155
	2 An Overview of the Tachykinin System	155
	3 Pharmacological Studies	157
	4 Generation of Knockout Mice	160
	5 Mechanism of Change in Phenotype in Tac1 and NK1R-Null Mutant Mice	168
	References	168
	Genetic Epidemiology of Anxiety Disorders	174
	1 Introduction	175
	2 Assessment and Definitions of Anxiety Disorder	175
	3 Familial and Genetic Factors	175
	4 Review of Family and Twin Studies of Anxiety Disorders in Adults	176
	5 Review of Linkage and Association Studies of Anxiety Disorders	177
	6 Family Studies and Phenotypic Definitions	179
	7 High-Risk Studies of Anxiety Disorders	180
	8 Future Directions for Research on Anxiety	181
	References	182
	Interactions Between Corticotropin-Releasing Hormone and Serotonin: Implications for the Aetiology and Treatment of Anxiety Disorders	191
	1 Introduction	192
	2 Neuroanatomical Basis for the Interactions Between CRH and Serotonin	194
	3 Effects of Central Administration of CRH and Related Peptides on Serotoninergic Neurotransmission	196
	4 Interactions Between CRH and Serotonin Under Anxiogenic and Psychologically Stressful Conditions: What CanWe Learn from In Vivo Microdialysis Studies?	199
	5 Consequences of Long-Term Changes in the CRH System for Hippocampal Serotoninergic Neurotransmission	206
	6 Conclusion	208
	References	208
	Anxiety Disorders: Noradrenergic Neurotransmission	215
	1 Neural Mechanisms of Anxiety and Fear	216
	2 Reconsolidation	219
	3 Extinction	220
	4 The Neurochemical Basis of Fear and Anxiety	222
	5 Noradrenergic System	222
	6 Posttraumatic Stress Disorder	226
	7 Panic Disorder	226
	8 Phobic Disorders	227
	9 Conclusion	227
	References	228
	Pathophysiology and Pharmacology of GABAA Receptors	234
	1 Inhibitory Interneurons	235
	2 Diversity of GABAA Receptors	238
	3 Pathophysiology of the GABA System	241
	4 Pharmacology of GABAA Receptor Subtypes	244
	5 Novel Subtype Selective Benzodiazepine Site Ligands	247
	References	249
	Excitatory Amino Acid Neurotransmission	257
	1 Introduction	258
	2 Glutamate Receptors	261
	3 Synaptic Plasticity	275
	4 Pathophysiology	277
	5 Summary	292
	References	293
	Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity	312
	1 Introduction	313
	2 Overview of Anxiety-Induced Signal Transduction and Neural Plasticity	314
	3 Cellular Mechanisms of Stress-Induced Structural Plasticity	320
	4 Intracellular Signaling Pathways Involved in Fear Memory	321
	5 Intracellular Signaling Pathways Involved in Anxiety	327
	6 Intracellular Signal Transduction Pathways in the Treatment of Anxiety	328
	7 Intracellular Pathways Regulated by Antidepressant Treatment	329
	8 Intracellular Pathways Regulated by Benzodiazepines	333
	9 Summary and Conclusions	334
	References	334
	Neuropeptides in Anxiety Modulation	342
	1 Neuropeptides	343
	2 Anxiety-Related Behaviour	345