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Glucose Sensing

:	Chris D. Geddes, Joseph R. Lakowicz
:	Chris D. Geddes, Joseph R. Lakowicz
:	Glucose Sensing
:	Springer-Verlag
:	9780387330150
:	1
:	CHF 131.40
:

:	Biochemie, Biophysik
:	English

:	442
:	Wasserzeichen
:	PC/MAC/eReader/Tablet
:	PDF

An essential reference for any laboratory working in the analytical fluorescence glucose sensing field. The increasing importance of these techniques is typified in one emerging area by developing non-invasive and continuous approaches for physiological glucose monitoring. This volume incorporates analytical fluorescence-based glucose sensing reviews, specialized enough to be attractive to professional researchers, yet appealing to a wider audience of scientists in related disciplines of fluorescence.

	PREFACE	6
	CONTRIBUTORS	7
	CONTENTS	10
	N-PHENYLBORONIC ACID DERIVATIVES OF ARENECARBOXIMDES AS SACCHARIDE PROBES WITH VIRTUAL SPACER DESIGN	20
	1.1. INTRODUCTION	20
	1.2. N-PHENYLBORONIC ACID ARENECARBOXIMIDES AS SACCHARIDE PROBES WITH VIRTUAL OR CO SPACER DESIGN	21
	1.3. SUBSTITUENT EFFECTS ON MONOBORONIC ACID DERIVATIVES OF N-PHENYLl, 8-NAPHTHALENEDICARBOXIMIDES	22
	1.4. POSITIONAL ISOMERS OF NAPHTHALENE DICARBOXIMIDES	32
	1.5. CONCLUSION	35
	1.6. SUMMARY AND OUTLOOK	36
	1.7. ACKNOWLEDGMENTS	36
	1.8. REFERENCES	36
	GENESIS OF FLUOROPHORE FORMATION IN MACROCYCLE SOLUTIONS AND THE DETECTION OF GLUCOSE AND RELATED SUGARS	40
	2.1. INTRODUCTION	40
	2.2. THE DISCOVERY OF NEW FUNCTIONAL FLUOROPHORES	40
	2.3. THE MECHANISM OF SUGARINDUCED SIGNAL TRANSDUCTION	47
	2.4. A HIGHLY CONVENIENT NEW AUTOMATED HPLC POSTCOLUMN DETECTION METHOD FOR MONITORING GLUCOSE AND RELATED BIOMOLECULES	53
	2.5. DETECTION OF GLUCOSE IN HUMAN BLOOD PLASMA AND PROGRESS TOWARDS CONCURRENT DETERMINATION OF GLUCOSE AND FRUCTOSE	57
	2.6. CONCLUSION	61
	2.7. ACKNOWLEDGMENTS	61
	2.8. REFERENCES	61
	TWO-COMPONENT OPTICAL SUGAR SENSING USING BORONIC ACID-SUBSTITUTED VIOLOGENS WITH ANIONIC FLUORESCENT DYES	65
	3.1. INTRODUCTION	65
	3.2. BACKGROUND AND ILLUSTRATION OF TWO-COMPONENT GLUCOSE SENSING - PYRANINE (HPTS) AND BORONIC ACID-FUNCTIONALIZED VIOLOGEN (o-BBV2+)	68
	3.3. VARIATIONS IN VIOLOGEN QUENCHER - BIPYRIDINIUM AND PHENANTHROLINIUM QUENCHERS	74
	3.4. VARIATIONS IN FLUORESCENT REPORTER - SULFONAMIDE DERIVATIVES OF HPTS	89
	3.5. IMMOBILIZATION OF THE SENSING COMPONENTS - A GLUCOSE SENSITIVE THIN FILM HYDROGEL	98
	3.6. SUMMARY AND FUTURE DIRECTIONS	101
	3.7. REFERENCES	102
	IMPLANTABLE CONCANAVLIN A BASED SENSORS FOR INTERSTITIAL FLUID GLUCOSE SENSING IN DIABETICS	106
	4.1. INTRODUCTION	106
	4.2. CONCANAVALIN A AND DEXTRAN	109
	4.3. FLUORESCENT BASED ASSAY	113
	4.4. SENSING MODALITIES	117
	4.5. SUMMARY	128
	4.6. REFERENCES	128
	FLUORESCENCE BIOSENSORS FOR CONTINUOUSLY MONITORING THE BLOOD GLUCOSE LEVEL OF DIABETIC PATIENTS	133
	5.1. INTRODUCTION	133
	5.2. GLUCOSE OXIDASE FROM ASPERGILLUS NIGER	135
	5.3. THERMOSTABLE GLUCOSE DEHYDROGENASE FROM THERMOPLASMA ACIDOPHILUM	137
	5.4. A FLUORESCENCE COMPETITIVE ASSAY BY USING THE STABLE GLUCOKINASE	139
	5.5. CONCLUSIONS	142
	5.6. ACKNOWLEDGMENT	143
	5.7. REFERENCES	143
	MICROCAPSULES AS	143
	147	143
	6.1. THE	143
	6.1. THE	143
	147	143
	6.2. LBL NANOFILMS AND POLYELECTROLYTE MICROCAPSULES	150
	6.3. GLUCOSE SENSORS FROM NANOENGINEERED CAPSULES	152
	6.4. ENZYME-BASED MICROCAPSULE SENSORS	158
	6.5. GLUCOSEBINDING PROTEINS IN MICROCAPSULES	172
	6.6. CONCLUSIONS	176
	6.7. ACKNOWLEDGEMENT	177
	6.8. REFERENCES	177
	NON-INVASIVE MONITORING OF DIABETES: Specificity, compartmentalization, and calibration issues	180
	7.1. INTRODUCTION	180
	7.2. SPECIFICITY OF NI GLUCOSE MEASUREMENTS	182
	7.3. COMPARTMENTALIZATION OF GLUCOSE VALUES	187
	7.4. CALIBRATION MODELS AND PATIENT-SPECIFIC CALIBRATION	187
	7.5. THERMO-OPTICAL RESPONSE OF HUMAN SKIN	188
	7.6. ENHANCING SPECIFICITY BY AFFINITY CAPTURE AGENTS	205
	7.7. CONCLUSIONS	210
	7.8. REFERENCES	211
	OPTICAL ENZYME-BASED GLUCOSE BIOSENSORS	215
	8.1. ABSTRACT	215
	8.2. INTRODUCTION	215
	8.3. OPTICAL TRANSDUCTION USING COMMON OPTICAL TRANSDUCERS	217
	8.4. IMMOBILIZATION OF GLUCOSE OXIDASE	221
	8.5. CONSTRUCTION OF GLUCOSE BIOSENSOR	229
	8.6. PERFORMANCE OF OPTICAL GLUCOSE BIOSENSOR	233
	8.7. IMPLICATION OF THE DISSOLVED OXYGEN CONCENTRATION	237
	8.8. ENHANCEMENT OF ENZYME STABILITY	238
	8.9. ANALYTICAL FEATURE AND APPLICATION	240
	8.10. CONCLUSION	242
	8.11. ACKNOWLEDGMENT	243
	8.12. REFERENCES	243
	SACCHARIDE RECOGNITION BY BORONIC ACID FLUOROPHORE/CYCLODEXTRIN COMPLEXES IN WATER	251
	9.1. ADVANCES IN SYNTHETIC RECEPTORS FOR SACCHARIDES	251
	9.2. SACCHARIDE RECOGNITION BY BORONIC ACID FLUOROPHORE ß-CYCLODEXTRIN COMPLEXES	256
	9.3. FUTURE PERSPECTIVE OF SUPRAMOLECULAR CYCLODEXTRIN COMPLEX SENSORS	268
	9.4. ACKNOWLEDGEMENT	270
	9.5. REFERENCES	271
	PLASMONIC GLUCOSE SENSING	273
	10.1. INTRODUCTION	273
	10.2. OPTICAL PROPERTIES OF GOLD NANOPARTICLES	274
	10.3. PREPARATION OF LIGAND FUNCTIONALIZED GOLD NANOPARTICLES FOR GLUCOSE SENSING AND OTHER APPLICATIONS	275
	10.4. PLASMONIC GLUCOSE SENSING	278
	10.5. CONCLUSIONS AND FUTURE DIRECTIONS	294
	10.6. ACKNOWLEDGMENTS	294
	10.7. REFERENCES	294
	OPTICALLY-BASED AFFINITY BIOSENSORS FOR GLUCOSE	297
	11.1. INTRODUCTION	297
	11.2. DEVELOPMENT OF OPTICALLY BASED BIOSENSORS	299
	11.3. COMPETITIVE OPTICAL AFFINITY GLUCOSE BIOSENSORS	303
	11.4. DYNAMICS OF AFFINITY BIOSENSORS	312
	11.5. RECENT DEVELOPMENTS IN AFFINITY BASED GLUCOSE BIOSENSOR SYSTEMS	313
	11.6. INTEGRAL BIOSENSOR PROTEINS	318
	11.7. ENHANCEMENTS OF OPTICAL GLUCOSE BIONSENSORS BASED ON AFFINITY PRINCIPLES	319
	11.8. CONCLUSION	321
	11.9. REFERENCES	321
	RECENT CHEMILUMINESCENCE APPLICATIOINS FOR GLUCOSE SENSING	325
	12.1. INTRODUCTION	325