| Preface | 6 |
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| Acknowledgments | 7 |
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| Contents | 8 |
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| Julian Theodore (Buz) Hoff 1936– 2007 | 12 |
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| Hoff Fellowships | 14 |
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| Experimental intracerebral hemorrhage – iron, hemoglobin and free radicals | 15 |
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| Deferoxamine therapy for intracerebral hemorrhage | 16 |
| Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage | 20 |
| Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage | 26 |
| The antioxidant effects of melatonin after intracerebral hemorrhage in rats | 32 |
| Poly(ADP-ribose) polymerase activation and brain edema formation by hemoglobin after intracerebral hemorrhage in rats | 35 |
| Induction of autophagy in rat hippocampus and cultured neurons by iron | 40 |
| Effects of superoxide dismutase and catalase derivates on intracerebral hemorrhage- induced brain injury in rats | 44 |
| Metallothionein and brain injury after intracerebral hemorrhage | 47 |
| Experimental intracerebral hemorrhage – inflammation and thrombin | 51 |
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| Intracerebral hemorrhage injury mechanisms: glutamate neurotoxicity, thrombin, and Src | 52 |
| Increase in brain thrombin activity after experimental intracerebral hemorrhage | 56 |
| Microglial activation and intracerebral hemorrhage | 60 |
| Concomitant intracerebral infusion of tissue plasminogen activator and thrombin leads to brain injury | 63 |
| Microglial activation and brain injury after intracerebral hemorrhage | 67 |
| Effects of aging on complement activation and neutrophil infiltration after intracerebral hemorrhage | 74 |
| Experimental intracerebral hemorrhage – other mechanisms | 78 |
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| Blood– brain barrier function in intracerebral hemorrhage | 79 |
| Treatment of stroke and intracerebral hemorrhage with cellular and pharmacological restorative therapies | 84 |
| Deficiency of CD18 gene reduces brain edema in experimental intracerebral hemorrhage in mice | 89 |
| Tissue inhibitor of matrix metalloproteinases-3 (TIMP-3) lacks involvement in bacterial collagenase- induced intracerebral hemorrhage in mouse | 92 |
| Radial glia marker expression following experimental intracerebral hemorrhage | 97 |
| Long-term effects of melatonin after intracerebral hemorrhage in rats | 100 |
| Management of delayed edema formation after fibrinolytic therapy for intracerebral hematomas: preliminary experimental data | 102 |
| Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood– brain barrier integrity in mice | 106 |
| Hyperbaric oxygen for experimental intracerebral hemorrhage | 114 |
| Effect of amantadine sulphate on intracerebral hemorrhage-induced brain injury in rats | 119 |
| Experimental intracerebral hemorrhage – model development and characterization | 122 |
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| Long-term behavioral characterization of a rat model of intracerebral hemorrhage | 123 |
| Neurological deficits and brain edema after intracerebral hemorrhage in Mongolian gerbils | 125 |
| Rat model of intracerebellar hemorrhage | 129 |
| A rat model of pontine hemorrhage | 133 |
| Human intracerebral hemorrhage | 136 |
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| The optimal time-window for surgical treatment of spontaneous intracerebral hemorrhage: result of prospective randomized controlled trial of 500 cases | 137 |
| Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation ( MISTIE) clinical trial | 142 |
| Pediatric cerebrovascular diseases: report of 204 cases | 147 |
| Xenon-CT study of regional cerebral blood flow around hematoma in patients with basal ganglia hemorrhage | 154 |
| Preliminary application of pyramidal tractography in evaluating prognosis of patients with hypertensive intracerebral hemorrhage | 158 |
| Experimental intracranial hemorrhage (non-intracerebral hemorrhage) | 164 |
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| Mechanisms and markers for hemorrhagic transformation after stroke | 165 |
| The clinical significance of acute brain injury in subarachnoid hemorrhage and opportunity for intervention | 171 |
| Development of a cerebral microvascular dysplasia model in rodents | 177 |
| Hyperbaric oxygen preconditioning protects against traumatic brain injury at high altitude | 182 |
| Human intracranial hemorrhage (non-intracerebral hemorrhage) | 188 |
| Genetic considerations relevant to intracranial hemorrhage and brain arteriovenous malformations | 189 |
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| Vasospasm after aneurysmal subarachnoid hemorrhage: need for further study | 197 |
| Regional cerebral blood flow and oxygen metabolism in aneurysmal subarachnoid hemorrhage: positron emission tomography evaluation of clipping versus coiling | 201 |
| Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage ( CLEAR- IVH) clinical trial | 206 |
| Leptin plays a role in ruptured human brain arteriovenous malformations | 210 |
| Novel treatments for cerebral vasospasm following aneurysmal subarachnoid hemorrhage | 214 |
| Relationship between serum sodium level and brain ventricle size after aneurysmal subarachnoid hemorrhage | 218 |
| Lack of association between apolipoprotein E promoters in e4 carriers and worsening on computed tomography in early stage of traumatic brain injury | 222 |
| Author index | 226 |
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| Index of keywords | 228 |
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