: Debra G. B. Leonard, Adam Bagg, Angela M. Caliendo, Karen L. Kaul, Vivianna M. Deerlin
: Debra G.B. Leonard
: Molecular Pathology in Clinical Practice
: Springer-Verlag
: 9780387332277
: 1
: CHF 208.90
:
: Klinische Fächer
: English
: 600
: DRM
: PC/MAC/eReader/Tablet
: PDF

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Preface6
Contents7
Contributors11
Basics of Molecular Biology18
Molecular Pathology Methods31
Genetics57
Genetic Counseling58
Pedigree Analysis and Risk Assessment64
Bayesian Analysis76
Developmental Disabilities88
Neuromuscular Diseases102
Molecular Genetic Testing for Metabolic Disorders112
Fibroblast Growth Factor Receptor–Related Skeletal Disorders123
Cystic Fibrosis131
Deafness138
Coagulation Disorders147
Hematologic Disorders: Hemochromatosis, Hemoglobinopathies, and Rh Incompatibility163
Cardiovascular Disease173
Neurodegenerative Disorders190
Skin and Connective Tissue Disorders201
Inherited Cancers214
Inherited Breast Cancer215
Familial Adenomatous Polyposis and Turcot and Peutz- Jeghers Syndromes223
Hereditary Nonpolyposis Colorectal Cancer231
Multiple Endocrine Neoplasia Syndromes241
The Neurofibromatoses251
TP53 Mutation and Li-Fraumeni Syndrome259
von Hippel-Lindau Disease270
Solid Tumors274
Breast Cancer275
Urothelial Carcinoma285
Sarcomas292
Gliomas303
Molecular Detection of Occult Tumor Cells309
Microarray Studies (Beyond Histology)316
Neoplastic Hematopathology322
Acute Myeloid Leukemia323
Acute Lymphoblastic Leukemia338
B-Cell Lymphomas349
T-Cell Lymphomas365
Lymphoproliferations of Immunodeficiency372
Myeloproliferative Disorders and Myelodysplastic Syndromes382
Infectious Diseases396
Human Immunodeficiency Virus Type 1397
Hepatitis B and C Viruses409
Viral Infections in Transplant Patients423
Viral Infections of the Central Nervous System434
Sexually Transmitted Diseases444
Respiratory Pathogens456
Bacterial Pathogens467
Mycobacterial Infections477
Identity Testing485
Forensic DNA Typing486
Parentage and Relationship Testing502
Assessment of Chimerism in the Setting of Allogeneic Hematopoietic Cell Transplantation511
Specimen Identification Through DNA Analysis526
HLA Typing531
Molecular HLA Typing532
Laboratory Management Issues542
Molecular Pathology Laboratory Management543
From Research to Clinical Practice566
Index572