: Douglas T. Carrell
: The Genetics of Male Infertility
: Humana Press
: 9781597451765
: 1
: CHF 97.30
:
: Klinische Fächer
: English
: 337
: Wasserzeichen/DRM
: PC/MAC/eReader/Tablet
: PDF

In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.

New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
PREFACE5
CONTENTS7
CONTRIBUTORS10
I METHODS AND TOOLS FOR THE STUDY OF THE GENETICS OF MALE INFERTILITY15
MALE INFERTILITY15
The Genetics of Male Infertility in the Era of Genomics16
The Use of cDNA Libraries to Demonstrate a Linkage Between Transcription and Translation in Male Germ Cells41
Considerations When Using Array Technologies for Male Factor Assessment48
Microarray Analysis of a Large Number of Single- Nucleotide Polymorphisms in Individual Human Spermatozoa66
Physiological and Proteomic Approaches to Understanding Human Sperm Function88
Genetics of Idiopathic Male Infertility109
MEIOSIS122
II MEIOSIS AND ERRORS OF MEIOSIS122
The Immunocytogenetics of Human Male Meiosis123
The Clinical Relevance of Sperm Aneuploidy137
DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility153
III THE Y CHROMOSOME, DEVELOPMENT, T SPERMATOGENESIS, AND SPERM MATURATION M172
Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis173
The Genetics of Cryptorchidism191
The Chromatoid Body and microRNA Pathways in Male Germ Cells205
Sperm Maturation in the Epididymis216
IV CLINICAL APPLICATIONS OF THE A STUDY OF THE GENETICS OF MALE M INFERTILITY237
The Structure of the Y Chromosome and Its Role in Male Infertility238
Y Chromosome Microdeletions and Haplotypes244
The Genetics of Male Infertility255
The Future of the Diagnosis of Male ( In) Fertility271
Polymorphisms and Male Infertility278
The Genetics of Abnormal Protamine Expression293
Chromatin Damage and Male Infertility304
Clinical Evaluation of the Genetics of Male Infertility317
Index329