Molecular Neurosurgery with Targeted Toxins
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Ronald G. Wiley, Douglas A. Lappi
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Ronald G. Wiley, Douglas A. Lappi
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Molecular Neurosurgery with Targeted Toxins
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Humana Press
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9781592598960
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1
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CHF 107.00
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Klinische Fächer
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English
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312
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Wasserzeichen
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PC/MAC/eReader/Tablet
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PDF
Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.
PREFACE
5
CONTENTS
6
CONTRIBUTORS
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Introduction to Molecular Neurosurgery
11
Ribosome-Inactivating Proteins
19
Biochemical, Physiological, and Behavioral Characterizations of the Cholinergic Basal Forebrain Lesion Produced by 192 IgG- Saporin
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Basal Forebrain Cholinergic Lesion by 192 IgG- Saporin
68
192 IgG-Saporin-Induced Partial Cortical Cholinergic Deafferentation as a Model for Determining the Interactions Between Brain Aging and Neurodevelopmental Defects in the Cortical Cholinergic Input System
96
Exploring the Role of Acetylcholine in Primate Cognition Using Me20.4 IgG- Saporin
110
Cortical Cholinergic Deafferentation Induces Aß Deposition
152
Chemical Dissection of Brain Glucoregulatory Circuitry
190
Cardiovascular Deficits After Lesions of C1 Adrenergic Neurons With a Saporin- Based Immunotoxin
228
Saporin Conjugates and Pain
243
The Use of Saporin Conjugates to Dissect Neurons Responsible for Sleep and Wakefulness
257
Isolectin IB4-Mediated Cytotoxic Targeting of Sensory Neurons
273
B Fragment of Cholera Toxin Conjugated to Saporin
300
Index
314
